Intramolecular cyclohexadienone annulations of Fischer carbene complexes: model studies for the synthesis of Phomactins.
نویسندگان
چکیده
The intramolecular cyclohexadienone annulation of chromium carbene complexes is examined as a method to provide general access to the Phomactin family of natural products. The importance of the stereochemistry of the carbene complex and the number of carbons in the tether connecting the carbene complex and the alkyne are probed. Additionally, the degree of the 1,4-asymmetric induction is examined.
منابع مشابه
Total synthesis of (+/-)-phomactin B2 via an intramolecular cyclohexadienone annulation of a chromium carbene complex.
Phomactins are novel platelet activating factor (PAF) antagonists isolated from the culture of marine fungus Phoma sp.1 Members of the phomactin family share a unique [9.3.1] pentadecane ring system, and their biosynthetic pathway shares a branchpoint with the taxane family of natural products.1,2 Substantial synthetic efforts have been described in the literature toward the synthesis of severa...
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عنوان ژورنال:
- Organic letters
دوره 9 15 شماره
صفحات -
تاریخ انتشار 2007